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Mural Unicystic Ameloblastoma Crossing the Midline: A Rare Case Report
Kumar, K,Kiran R; George,Giju Baby; Padiyath,Sheeba; Rupak,S;
International journal of odontostomatology , 2012, DOI: 10.4067/S0718-381X2012000100014
Abstract: ameloblastoma is a benign odontogenic neoplasm which frequently affects the mandible. the term ameloblastoma includes several clinico-radiological and histological types. apart from the most commonly encountered clinico- pathologic models there are few variants, whose biological profile is unknown or not elicited. the reason for lack of understanding is the scarcity of case report published in the literature. among the types, unicystic ameloblastoma is the least encountered either it presents as unilocular or multilocular radiolucency, but peculiar radiographic presentation of multilocular radiolucency in posterior mandible with unilocular radiographic appearance crossing the midline is extremely rare, which has not been reported yet. here we report a distinctive case of mural unicystic ameloblastoma of mandible in a 17-year- old- girl with the radiographic presentation as mentioned above.
Biological activity of the red alga Laurencia brandenii
Aseer Manilal , Sugathan Sujith , Balu Sabarathnam , George S. Kiran , Joseph Selvin , Chippu Shakir , Aaron P. Lipton
Acta Botanica Croatica , 2011, DOI: 10.2478/v10184-010-0001-x
Abstract: The marine red alga Laurencia brandenii collected from the southwest coast of India (Indian Ocean) was extracted and fractioned using column chromatography. The individual fractions were evaluated in vitro via antimicrobial activity against six species of Microbial Type Culture Collection and three species of clinical human pathogens, antipest activity on Sitophilus oryzae, maggoticidal activity against 2nd instar larvae of Sarcophaga sp. and termiticidal activity against Microtermes obesi. It was found that the fraction eluted using petroleum ether:chloroform (6:4) exhibited broader biological activities. The phyco-constituents of the active fraction were identified by gas chromatography-mass spectrometry (GC-MS) analysis. The GC-MS profile of the active fraction revealed that the main constituent was octadecadienoic acid (49.75%) followed by n-hexadecanoic acid (14.24%), which might have a functional role in the biological activities. The overall activity profile envisages that these bioactive compounds from L. brandenii could be utilized as a renewable natural resource for the development of novel environmental-compatible formulations for the control of human pathogens, pests, termites and maggots.
Biological activity of red alga Laurencia brandenii
Kiran, George S.,Lipton, Aaron P.,Manilal, Aseer,Sabarathnam, Balu,Selvin, Joseph,Shakir, Chippu,Sujith, Sugathan
- , 2011,
Abstract: Sa？etak The marine red alga Laurencia brandenii collected from the southwest coast of India (Indian Ocean) was extracted and fractioned using column chromatography. The individual fractions were evaluated in vitro via antimicrobial activity against six species of Microbial Type Culture Collection and three species of clinical human pathogens, antipest activity on Sitophilus oryzae, maggoticidal activity against and instar larvae of Sarcophaga sp. and termiticidal activity against Microtermes obesi. It was found that the fraction eluted using petroleum ether:chloroform (6:4) exhibited broader biological activities. The phyco-constituents of the active fraction were identified by gas chromatography- -mass spectrometry (GC-MS) analysis. The GC-MS profile of the active fraction revealed that the main constituent was octadecadienoic acid (49.75%) followed by n-hexadecanoic acid (14.24%), which might have a functional role in the biological activities. The overall activity profile envisages that these bioactive compounds from L. brandenii could be utilized as a renewable natural resource for the development of novel environmental-compatible formulations for the control of human pathogens, pests, termites and maggots
Caudal and Penile Blocks Demonstrate Similar Reliability and Efficacy in Pediatric Patients Undergoing Circumcision: A Meta-Analysis  [PDF]
Kiran Malik, Ronald S. Chamberlain
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.75033
Abstract: Purpose: Circumcision is one of the most common surgeries performed in the pediatric population. Multiple regional analgesic techniques, including caudal (CB) and penile block (PB), have championed as offering optimal analgesia for circumcision in the post-neonatal pediatric population without clear consensus. This meta-analysis sought to investigate CB and PB’s analgesic efficacy and the impact on postoperative analgesic requirements in pediatric circumcisions. Methods: A comprehensive literature search of PubMed, Google Scholar, and Cochrane Library (1966-2016) was completed to identify all published randomized control trials (RCTs). Keywords searched included “circumcision”, “caudal block”, “penile block”, and “analgesia”. Inclusion criteria were limited to the comparison of PB versus CB in children less than 18 years of age and its efficacy towards circumcision. The efficacy, time to first additive analgesia, time to first micturition, duration of prolonged motor blockade, incidence of vomiting, and length of stay were analyzed. Results: 9 RCTs involving 574 children (N = 287 in CB and PB) were included. No differences in analgesic efficacy (relative risk (RR) = 0.983, 95% confidence interval (CI) = 0.95 to 1.02; p = 0.328) or time to first additive analgesia were observed (standardized difference in mean (SDM) = 0.438, 95% CI = -0.04 to 0.92; p = 0.073). Time to first micturition (SDM = 0.680, 95% CI = 0.40 to 0.96; p < 0.001) and motor block duration (SDM = 0.707, 95% CI = 0.19 to 1.22; p = 0.007) were significantly prolonged in patients receiving CB. No differences were observed between groups in regards to the incidence of vomiting (RR = 1.56, 95% CI = 0.91 to 2.67; p = 0.107) and length of stay (SDM = 0.741, 95% CI = -0.05 to 1.53; p = 0.066). Conclusion: CB and PB offer similar analgesic success rates for pediatric patients (age 18 months to 16 years) undergoing circumcision. CB is associated with a trend towards longer duration of analgesia, but is associated with prolonged urinary retention and delayed ambulation. CB use is recommended in non-ambulatory children, whereas PB is recommended in ambulatory children.
Case study: An unusual cause of clotted blood in epidural catheter
S Kiran
Southern African Journal of Anaesthesia and Analgesia , 2010,
Abstract: The failure of an epidural catheter after initially functioning well may be due to kinking, knotting or epidural catheter lumen blockage. The presence of blood in the epidural catheter is usually due to the catheter’s traumatic placement or to intravascular migration. We describe an unusual cause of blood in the epidural catheter.
Increasing Incidence of Diabetes Mellitus, Systemic Hypertension and Germ Cells with Endogenous Estrogen  [PDF]
Elizabeth Jeya Vardhini Samuel, Nagarajan Natarajan, Sanjoy George, Kiran Gkulirankal, George Eapen
Open Journal of Preventive Medicine (OJPM) , 2014, DOI: 10.4236/ojpm.2014.46056
Abstract:

Background: Era of contraception, abortions, [20th, 21st centuries] implemented as family welfare schemes, witnessed increased global incidence of Type 2 diabetes mellitus, systemic hypertension. Objectives: Altruistic association of contraception [if any], with increasing diabetes mellitus, systemic hypertension, was sought after. Methods: In 2012, retrospective analysis of, prevalence of diabetes mellitus, systemic hypertension, in 350 patients of 20 - 35 years, 35 - 50 years, >50 years, age groups, data collected by convenient, stratified random sampling, from different geographical locations, between 2003-2012 and its association with presence, absence of contraception, abortion was undertaken; simultaneously, serum estrogen levels obtained from 105 patients, were also analysed. Results: 10 - 45 fold increase in Type 2 diabetes mellitus was seen in contraceptive users of >20 years to >50 years; 15 - 50 fold increase in incidence of systemic hypertension was seen in contraceptive users of >20 years to >50 years. Endogenous estrogen was reduced below normal in 75% of contraceptive users, and 25% of contraceptive users had low normal serum estrogen. Cholesterol deprived diet, due to decreased synthesis of endogenous estrogen, androgen also was associated with 50% increase in diabetes mellitus, systemic hypertension. Conclusion: Concept is acquired contraception, abortion status, with smashed fragmentation of germ cells, reduced endogenous estrogen, androgen, results in defaulted genomic repertoire, deranged cell metabolism, increased incidence of diabetes mellitus, systemic hypertension as part of metabolic syndrome. Contraception reversal declined the diseases as a cause and effective phenomenon.

Detection of Genetic Components of Variation for Yield, Fibre and Quality Traits in Flax (Linum usitatissimum L.)
Kiran Kiran,V. K. Sood,S. Bhateria
Journal of Agricultural Science , 2012, DOI: 10.5539/jas.v4n10p224
Abstract: The research was carried out using generation mean analysis derived from crosses of TL-11 x Him Alsi-2, Turkey x Binwa and TL-43 x Binwa at two locations i.e. E1 and E2. Out of the three crosses, TL -11 x Him Alsi-2 was the best cross in both the locations. This cross invariably has given 2-3 times higher yield than the remaining crosses. Therefore, the results obtained in the present investigation with respect to the above best cross for generation mean analysis suggested that both additive and dominance gene effects were important for most of the traits but dominance was predominant as compared to additive effects. Duplicate type of gene action was observed in the expression of days to 50 per cent flowering, seed yield per plant, plant height, technical height and fibre traits in E2 for the above cross which implies the use of biparental approach and selection to be deferred to later generations. Complimentary type of gene action was observed for biological yield per plant, seed yield per plant which implies the use of biparental approach and early generation selection. Therefore, it appears worthwhile to go for biparental matings or few cycles of recurrent selection for the accumulation of favourable genes for seed yield and its components in linseed. Different breeding strategy for crosswise as well as location wise is suggested because gene action was different in two locations.
Protein-induced membrane curvature changes membrane tension
Padmini Rangamani,Kranthi Kiran Mandadapu,George Oster
Quantitative Biology , 2014, DOI: 10.1016/j.bpj.2014.06.010
Abstract: Adsorption of proteins onto membranes can alter the local membrane curvature. This phenomenon has been observed in biological processes such as endocytosis, tubulation and vesiculation. However, it is not clear how the local surface properties of the membrane, such as membrane tension, change in response to protein adsorption. In this paper, we show that the classical elastic model of lipid membranes cannot account for simultaneous changes in shape and membrane tension due to protein adsorption in a local region, and a viscous-elastic formulation is necessary to fully describe the system. Therefore, we develop a viscous-elastic model for inhomogeneous membranes of the Helfrich type. Using the new viscous-elastic model, we find that the lipids flow to accommodate changes in membrane curvature during protein adsorption. We show that, at the end of protein adsorption process, the system sustains a residual local tension to balance the difference between the actual mean curvature and the imposed spontaneous curvatures. This change in membrane tension can have a functional impact in many biological phenomena where proteins interact with membranes.
Anaesthetic management of appendectomy in a patient with cerebral arteriovenous malformation
R Taneja, S Kiran
Southern African Journal of Anaesthesia and Analgesia , 2010,
Abstract: Background: The aim of anaesthetic management for appendectomy in a patient with cerebral arteriovenous malformation (AVM) is to maintain a stable cardiovascular system. As this condition is rare, there are no definitive guidelines regarding the anaesthetic management of such patients. Case report: We report a case of appendectomy in a patient with cerebral AVM. The patient was diagnosed with cerebral AVM four years prior to presentation with acute appendicitis and was advised surgical intervention, which he refused. Management of this patient presenting with acute appendicitis is discussed. Conclusion: General anaesthesia may be used successfully for appendectomy in a patient with cerebral AVM if haemodynamic fluctuations at times of stress are minimised.
Evaluation of gabapentin in attenuating pressor response to direct laryngoscopy and tracheal intubation
S Kiran, D Verma
Southern African Journal of Anaesthesia and Analgesia , 2008,
Abstract: Background: To evaluate effect of gabapentin in attenuation of haemodynamic responses to direct laryngoscopy and tracheal intubation. Methods: Hundred patients undergoing elective surgery were randomly allocated to two groups of 50 patients each. Patients in group A received gabapentin 800 mg and patients in group B received placebo capsules the night before and on the morning of surgery. Anaesthesia was induced with propofol and vecuronium. Systolic, diastolic, mean arterial blood pressures (SAP, DAP, MAP) and heart rate (HR) were recorded before and after the induction of anesthesia and 0, 1, 3, 5 and 10 min after tracheal intubation. Results: SAP was significantly lower in the gabapentin as compared to the control group 0, 1, 3, 5 and 10 min after intubation [121 vs 135 (P < 0.001), 117 vs 132 (P < 0.001), 112 vs 124 (P < 0.001), 110 vs 118 (P < 0.05) and 107 vs 112 (P < 0.05) respectively]. DAP also was lower in the gabapentin group 0, 1, 3, and 5 min after intubation [77 vs 87 (P < 0.001), 74 vs 84 (P < 0.001), 70 vs 78 (P < 0.001) and 68 vs 74 (P < 0.05)]. MAP also was lower in the gabapentin group 0, 1, 3, and 5 min after intubation [92 vs 103 (P < 0.001), 88 vs 100 (P < 0.001), 84 vs 93 (P < 0.001) and 82 vs 88 (P < 0.05)]. HR also was lower in the gabapentin group 0, 1 and 3 min after intubation [90 vs 98 (P < 0.05), 88 vs 95 (P < 0.001) and 84 vs 90 (P < 0.05)]. Conclusion: Gabapentin, under the present study design attenuates the pressor response associated with laryngoscopy and tracheal intubation but tachycardiac response is not completely eliminated.
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